Sir William Drury (2 October 1527 – 13 October 1579) was an English statesman and soldier. In 1576, he was sent to Ireland as President of Munster, where his rule was severe but effective, and in 1578 he became Lord Justice of Ireland, taking the chief control of affairs after the departure of Sir Henry Sidney.

He was engaged in resisting the rebellion of the Earl of Desmond in the summer of 1579 when he died of illness at Waterford in Oct. He was buried in St. Patrick's Cathedral. A monument bearing his effigy was erected some time later, but no longer exists. His house in London gave its name to the street Drury Lane.