Though earlier land-reclamation along the Liffey's south-eastern banks had allowed for construction in the area, as evidenced by the quay's name, its current layout derives from Dublin's "Georgian" development period in the 18th century. Most remaining buildings on the quay however date from 19th and (predominantly) 20th century construction.

The quay is fronted primarily by George's Quay Plaza - a complex of buildings located between Hawkins street and Lombard Street. It is sometimes jokingly referred to as "Canary Dwarf" in reference to Canary Wharf in London.